Thomas Kuhn had physics in mind when he wrote Structure of scientific revolutions but his key ideas also apply to statistics and systems biology and can explain some of the confusion in the field.
Thomas Kuhn’s Structure of scientific revolutions desribes the history of science as phases of normal science separated by revolutions and paradigm shifts. During normal science, research is guided by a ruling paradigm, which identifies feasible problems and routes to tackle them. Normal science is a period of puzzle solving. The better your paradigm, the clearer the puzzle, the better your chances to solve it and progress.