Science

Tracking the Evolutionary History of a Tumor @ The Scientist

Check out Amber Dance’s comparison of single cell tumor phylogeny methods at The Scientist.

http://www.the-scientist.com/?articles.view/articleNo/48972/title/Tracking-the-Evolutionary-History-of-a-Tumor/

Almost makes it look like Niko and I know what we are doing in this field.

Florian

Science

Research Highlight: Computing tumor trees from single cells

Edith‘s OncoNEM paper made it into the Genome Biology Special Issue on Single-Cell Omics, together with a paper on a tree inference method called SCITE by Niko Beerenwinkel’s group.

If you need any more evidence that our two papers were -at least in my totally unbiased opinion- the obvious highlights of the whole Special Issue, just observe that Alexander Davis and Nick Navin chose us to write a Research Highlight about. They conclude:

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Science

Inferring tumor evolution from single-cell genomes

Series on Tumor Evolution

Everything is better if you do it with a Nested Effects Model – even inferring tumor evolution.

Let me introduce to you Oncogenetic Nested Effects Models, or for short OncoNEMs, which we just published in the new Single Cell collection of Genome Biology (see here). They exploit the fact that tumors accumulate mutations while they evolve, which leads to (noisy) subset relations between clones – exactly the type of pattern NEMs were made for.

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