Trevor and Andrea just published a really nice review in the Journal of Pathology:
Measuring cancer evolution from the genome
In this review, we describe how a cancer’s genome can be analysed to reveal the temporal history of mutation and selection, and discuss why both selective and neutral evolution feature prominently in carcinogenesis. We argue that selection in cancer can only be properly studied once we have a handle on what the absence of selection looks like. We review the data describing punctuated evolution in cancer, and reason that punctuated phenotype evolution is consistent with both gradual and punctuated genome evolution.
Even Hopeful Monsters make an appearance – I predict they are the next big thing in cancer research!